Ecosystem @ Molecule + VitaDAO with product, design and dev background exploring decentralized science and longevity.



"Metascience is the use of scientific methodology to study science itself. Metascience seeks to increase the quality of scientific research while reducing inefficiency."

Metascience is the study of the methods and procedures used in scientific research. It is concerned with the identification and characterization of the basic elements of scientific inquiry, and with the ways in which these elements interact to produce reliable knowledge.

Metascience is not primarily concerned with the interpretation or justification of scientific theories, as philosophy of science is. Rather, its focus is on the study of scientific methods and procedures, and on the ways in which they can be improved.

There are four main goals of metascience:

  1. To identify the basic elements of scientific inquiry
  2. To characterize the ways in which these elements interact
  3. To determine the conditions under which scientific knowledge is produced
  4. To develop ways of improving the quality and reliability of scientific research

Science Progress

Science productivity could be further improved. Focused Research Organizations and ideas like Private ARPA show one potential solution. This type of organization starts with a goal in mind and works backward to get there. The core idea is that sometimes scientific progress requires putting existing building blocks together with a bigger engineering effort to realize them.  

Reproducibility Crisis

The reproducibility crisis in science is a problem that has been increasing in recent years. Scientists are finding it harder and harder to reproduce the results of their experiments, and this is having a major impact on the progress of science.

There are a number of reasons for this crisis. One is that experiments are becoming more and more complex, making it harder to control all the variables. Another is that there is increasing pressure on scientists to publish their results, which can lead to them cutting corners in their experiments.

However, there are ways to solve this problem. One is to improve the way experiments are designed, so that they are more reproducible. Another is to provide more funding for replication studies, which are essential for confirming the results of experiments.

The reproducibility crisis in science is a serious problem, but it is one that we can solve. By taking steps to improve the design of experiments and to fund replication studies, we can ensure that science progresses in a robust and reliable way.

Some foundational research might be fundamentally flawed or outright fabricated, which is why we progress in ensuring important, foundational science successfully reproduces might be fundamental to overall scientific progress.


Applied positive meta-science by José Ricon; Summary

  1. Finding more building blocks: better scientific tools, models, datasets etc.
  2. Tools for (scientific) thought: better tools for all steps of science
  3. Time is all you need? Freeing up scientists time from grants, administrative and manual work etc.
  4. Various proposals to improve science: Software, Tooling, New Institutions, Funding mechanisms, Activities and norms


Tech Trees

“While Civilization is just a game, the framework of tech trees can be helpful for thinking about scientific progress in the real world. Every technology can be seen through the lens of the foundational research that made it possible and the future discoveries it enables. However, there is one major difference between the game and reality: In the game, you can scroll to the end of the tech tree to decide whether going down a particular branch will pay dividends in the future. In the real world, the future is unknown, so it’s up to us to imagine new technologies.” –




Science is broken visualization by José Ricon

Science is broken graphic